OncologyIn Clinical Trials

Plitidepsin (Aplidin)

Intravenous

Overview

Plitidepsin is a cyclic depsipeptide originally isolated from the Mediterranean tunicate Aplidium albicans and now produced synthetically. It targets the eukaryotic elongation factor 1A2 (eEF1A2), leading to oxidative stress, cell cycle arrest, and apoptosis in malignant cells.

Mechanism of Action

The compound has demonstrated activity against multiple myeloma and other hematologic malignancies in preclinical models. Its unique mechanism distinguishes it from conventional chemotherapeutic agents..

Research Summary & Key Findings

Phase III trials in relapsed/refractory multiple myeloma did not meet primary endpoints for progression-free survival compared to standard therapies. Plitidepsin received conditional approval in Australia in 2018 for multiple myeloma but has not achieved FDA approval. It has also been investigated for antiviral activity, including preliminary studies in COVID-19.

Clinical Status

In Clinical Trials

Plitidepsin (Aplidin) is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.

Administration Routes

Intravenous

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.