MetabolicFDA Approved

Liraglutide (Saxenda/Victoza)

Subcutaneous injection (daily)

Overview

A GLP-1 receptor agonist with 97% homology to native GLP-1, modified with a fatty acid side chain (C-16 palmitoyl) enabling albumin binding and a half-life of approximately 13 hours. Liraglutide enhances glucose-dependent insulin secretion, suppresses glucagon, delays gastric emptying, and promotes satiety through hypothalamic GLP-1R activation.

Mechanism of Action

It was the first GLP-1 RA approved for chronic weight management..

Research Summary & Key Findings

SCALE trials demonstrated 5-8% mean body weight reduction. LEADER trial showed cardiovascular benefit with 13% reduction in MACE in type 2 diabetes patients. FDA-approved for type 2 diabetes (Victoza, 2010) and chronic weight management (Saxenda, 2014).

Clinical Status

FDA Approved

Liraglutide (Saxenda/Victoza) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection (daily)

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.