Imuthiol (Diethyldithiocarbamate)
Overview
Imuthiol is the sodium salt of diethyldithiocarbamate, a small molecule rather than a peptide, historically explored for immune modulation and antiviral properties. It is thought to alter cytokine profiles and scavenge reactive oxygen species.
Mechanism of Action
Therapeutic interest has focused on HIV infection and other states of immune dysregulation..
Research Summary & Key Findings
Early clinical trials in the late 1980s and early 1990s investigated imuthiol in HIV-positive patients, with some studies reporting transient increases in CD4 counts but no durable virologic or clinical benefit. Subsequent development was discontinued due to lack of efficacy in later-stage trials.
Clinical Status
Imuthiol (Diethyldithiocarbamate) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
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