ImmuneFDA Approved

Icatibant (Firazyr)

Subcutaneous injection

Overview

A synthetic decapeptide bradykinin B2 receptor antagonist containing five non-natural amino acids for enhanced stability and receptor selectivity. Icatibant competitively blocks bradykinin, the primary mediator of swelling in hereditary angioedema (HAE) caused by C1 esterase inhibitor deficiency.

Mechanism of Action

By preventing bradykinin-induced vasodilation and increased vascular permeability, it rapidly reverses mucosal and subcutaneous edema..

Research Summary & Key Findings

FDA-approved in 2011 for acute attacks of hereditary angioedema in adults. FAST-3 trial demonstrated significant reduction in time to onset of symptom relief (2.0 hours vs. 19.8 hours for placebo) and time to almost complete symptom relief (Lumry et al., Ann Allergy Asthma Immunol, 2011). Self-administered via prefilled syringe, enabling on-demand home treatment. Second dose may be administered if symptoms persist or recur.

Clinical Status

FDA Approved

Icatibant (Firazyr) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.