ReproductiveFDA Approved

Follitropin Alfa (Gonal-F)

Subcutaneous injection

Overview

Follitropin alfa is a recombinant human follicle-stimulating hormone produced in Chinese hamster ovary cells, consisting of a heterodimeric glycoprotein with 92-amino acid alpha and 111-amino acid beta subunits. The peptide binds FSH receptors on ovarian granulosa cells to stimulate follicular development, estradiol synthesis, and oocyte maturation.

Mechanism of Action

It is employed in ovulation induction and controlled ovarian stimulation for assisted reproductive technologies..

Research Summary & Key Findings

FDA approval was obtained in 1997 following randomized trials demonstrating equivalence to urinary FSH in inducing ovulation and comparable pregnancy rates in IVF cycles. Long-term registry data have confirmed safety and efficacy across diverse patient populations. The recombinant formulation offers greater purity and consistency compared to urinary-derived gonadotropins.

Clinical Status

FDA Approved

Follitropin Alfa (Gonal-F) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.