MetabolicIn Clinical Trials

Ecnoglutide

Subcutaneous injection

Overview

Ecnoglutide is a long-acting GLP-1 receptor agonist peptide designed for once-weekly subcutaneous administration. It acts by enhancing glucose-dependent insulin secretion, reducing glucagon levels, and delaying gastric emptying to improve glycemic control and promote weight loss.

Mechanism of Action

The extended half-life is achieved through structural modifications that resist enzymatic degradation and renal clearance..

Research Summary & Key Findings

Phase 2 trials in adults with type 2 diabetes have demonstrated reductions in HbA1c and body weight consistent with the GLP-1 agonist class. Safety data showed a typical profile of gastrointestinal adverse events. Further development is needed to establish positioning relative to existing long-acting GLP-1 therapies.

Clinical Status

In Clinical Trials

Ecnoglutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.

Administration Routes

Subcutaneous injection

Related Peptides in Metabolic

Semaglutide (Ozempic/Wegovy)

FDA Approved

A glucagon-like peptide-1 receptor agonist (GLP-1 RA) with 94% amino acid homology to native GLP-1. Semaglutide enhances...

View details

Tirzepatide (Mounjaro/Zepbound)

FDA Approved

A first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Tirzepatide activat...

View details

Retatrutide

In Clinical Trials

An investigational triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. The gluc...

View details

AOD-9604

Investigational

A modified 16-amino acid fragment (amino acids 176-191) of the C-terminus of human growth hormone with an added tyrosine...

View details

Find a Provider

Find a verified provider who offers Ecnoglutide therapy in your area.

Browse Provider Map

Find a Pharmacy

Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Ecnoglutide.

Pharmacy Directory

Join the Association

Access exclusive peptide protocols, provider resources, and community support.

List Your Practice

Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.