ReproductiveFDA Approved

Corifollitropin Alfa (Elonva)

Subcutaneous injection

Overview

Corifollitropin alfa is a recombinant long-acting FSH analogue created by fusing the C-terminal peptide of the hCG beta subunit to the FSH beta chain. This structural modification extends the elimination half-life to approximately 70 hours, enabling a single injection to sustain follicular stimulation for seven days.

Mechanism of Action

The agent is designed to simplify controlled ovarian stimulation protocols by replacing the first week of daily FSH injections in IVF cycles..

Research Summary & Key Findings

FDA approval was granted in 2014 following the Ensure and Engage trials, which demonstrated non-inferiority to daily recombinant FSH in oocyte yield and ongoing pregnancy rates. Studies published in The Lancet and Fertility and Sterility confirmed reduced injection burden with comparable safety profiles. The agent is now approved in multiple countries for use in women undergoing ART.

Clinical Status

FDA Approved

Corifollitropin Alfa (Elonva) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.