ReproductiveFDA Approved

Choriogonadotropin Alfa (Ovidrel)

Subcutaneous injection

Overview

Choriogonadotropin alfa is a recombinant human chorionic gonadotropin produced in Chinese hamster ovary cells with identical amino acid sequence to endogenous hCG. The 237-amino acid heterodimeric glycoprotein binds the LH/hCG receptor on ovarian granulosa and theca cells to trigger final oocyte maturation and ovulation.

Mechanism of Action

It is used in assisted reproductive technology protocols to time oocyte retrieval and support luteal phase progesterone production..

Research Summary & Key Findings

FDA approval was granted in 2000 following controlled trials demonstrating comparable efficacy to urinary-derived hCG in triggering ovulation and supporting ART outcomes. Multicenter studies published in Fertility and Sterility confirmed equivalent pregnancy rates with improved dosing consistency due to recombinant production. The agent is now a standard component of ovulation induction and IVF protocols worldwide.

Clinical Status

FDA Approved

Choriogonadotropin Alfa (Ovidrel) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.