OncologyIn Clinical Trials

Buserelin (Suprefact)

Subcutaneous injection, Intranasal

Overview

Buserelin is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a potent GnRH agonist. It binds with high affinity to pituitary GnRH receptors, initially stimulating gonadotropin release before inducing receptor desensitization and downregulation, ultimately suppressing sex hormone production.

Mechanism of Action

The peptide is used primarily in the management of hormone-dependent prostate cancer and endometriosis. Structural modifications include substitution of glycine at position 6 with D-serine and replacement of the C-terminal glycine amide with an ethylamide group to enhance potency and duration of action..

Research Summary & Key Findings

Buserelin has been approved in multiple international markets, including Europe and Canada, since the 1980s for prostate cancer and assisted reproductive technology applications, though it is not FDA-approved in the United States. Clinical trials have demonstrated castration rates exceeding 85% in prostate cancer patients, with efficacy comparable to other GnRH agonists. It is available in multiple formulations including subcutaneous depot, intranasal, and subcutaneous injection forms to accommodate different clinical scenarios.

Clinical Status

In Clinical Trials

Buserelin (Suprefact) is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.

Administration Routes

Subcutaneous injectionIntranasal

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.