Beta-Defensin 3
Overview
Beta-defensin 3 (hBD-3) is an antimicrobial peptide of approximately 45 amino acids with potent activity against a wide range of pathogens, including antibiotic-resistant strains. It acts by permeabilizing microbial membranes and modulating host immune responses.
Mechanism of Action
Therapeutic applications include topical antimicrobial therapy and vaccine adjuvants..
Research Summary & Key Findings
In vitro and animal studies have demonstrated hBD-3 efficacy against methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Candida species. Translation to clinical use has been limited by challenges in large-scale synthesis and formulation stability, with no approved products to date.
Clinical Status
Beta-Defensin 3 is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
Related Peptides in Immune
Thymalin
InvestigationalA peptide bioregulator originally extracted from bovine thymus gland, consisting of a mixture of polypeptides that modul...
View detailsLL-37
Research PhaseThe only human cathelicidin antimicrobial peptide, a 37-amino acid cationic peptide cleaved from the precursor protein h...
View detailsVIP (Vasoactive Intestinal Peptide)
InvestigationalA 28-amino acid neuropeptide widely distributed in the central and peripheral nervous systems and immune cells. VIP acts...
View detailsThymosin Alpha 1 (Zadaxin)
InvestigationalA 28-amino acid peptide originally isolated from thymic tissue (thymosin fraction 5) that serves as a potent immunomodul...
View detailsFind a Provider
Find a verified provider who offers Beta-Defensin 3 therapy in your area.
Browse Provider MapFind a Pharmacy
Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Beta-Defensin 3.
Pharmacy DirectoryJoin the Association
Access exclusive peptide protocols, provider resources, and community support.
List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol.