Apraglutide
Overview
Apraglutide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist designed to promote intestinal growth and improve absorption in patients with short bowel syndrome. The peptide analogue shares structural homology with native GLP-2 but incorporates modifications that extend its half-life and enhance resistance to dipeptidyl peptidase-4 degradation.
Mechanism of Action
By binding to GLP-2 receptors in the intestinal epithelium, apraglutide stimulates crypt cell proliferation and reduces gastric emptying and secretion, supporting adaptive intestinal function..
Research Summary & Key Findings
Phase 3 trials in adults with short bowel syndrome dependent on parenteral support have demonstrated significant reductions in parenteral nutrition volume requirements compared to placebo. The compound has been studied primarily in patients with remnant colon or jejunostomy configurations, with published data appearing in Gastroenterology and related specialty journals since 2020.
Clinical Status
Apraglutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
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