Angiotensin (1-7)
Overview
Angiotensin (1-7) is a seven-amino acid peptide component of the renin-angiotensin system formed through cleavage of angiotensin II by ACE2 or from angiotensin I by endopeptidases. It binds to the Mas receptor to produce vasodilation, anti-proliferative, anti-fibrotic, and anti-inflammatory effects that generally oppose the actions of angiotensin II.
Mechanism of Action
This counter-regulatory arm of the renin-angiotensin system represents a therapeutic target in hypertension, heart failure, and renal disease..
Research Summary & Key Findings
Preclinical studies have demonstrated that angiotensin (1-7) reduces blood pressure, attenuates cardiac remodeling, and improves endothelial function in animal models of cardiovascular disease. Clinical development has been limited by the peptide's short half-life, though modified analogues and oral formulations are under investigation without published phase 3 trial results.
Clinical Status
Angiotensin (1-7) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
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