Thymulin

A peptide bioregulator originally extracted from bovine thymus gland, consisting of a mixture of polypeptides that modulate immune function. Thymalin restores T-cell mediated immunity by promoting T-lymphocyte maturation and differentiation in the thymus. It also normalizes the ratio of T-helper to T-suppressor cells and enhances phagocytic activity of neutrophils and macrophages.

The only human cathelicidin antimicrobial peptide, a 37-amino acid cationic peptide cleaved from the precursor protein hCAP18. LL-37 disrupts microbial membranes through electrostatic interactions and exerts broad-spectrum activity against bacteria, fungi, and enveloped viruses. Beyond direct antimicrobial effects, it modulates innate immunity by recruiting immune cells, promoting angiogenesis, and regulating inflammatory cytokine release.

A 28-amino acid neuropeptide widely distributed in the central and peripheral nervous systems and immune cells. VIP acts through VPAC1 and VPAC2 receptors to produce potent anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12) and promoting regulatory T-cell differentiation. It also functions as a vasodilator, bronchodilator, and neuromodulator.

A 28-amino acid peptide originally isolated from thymic tissue (thymosin fraction 5) that serves as a potent immunomodulator. Thymosin alpha 1 enhances T-cell maturation, dendritic cell function, and antibody responses by activating Toll-like receptors (TLR2, TLR9) on innate immune cells. It promotes Th1 immune responses and augments vaccine efficacy while modulating inflammatory cytokine production.