PT-141 (Bremelanotide / Vyleesi)
Overview
A synthetic cyclic heptapeptide melanocortin receptor agonist that activates MC3R and MC4R in the central nervous system. Unlike PDE5 inhibitors that act peripherally on vascular smooth muscle, PT-141 works centrally through hypothalamic melanocortin pathways that modulate sexual arousal and desire. It is a metabolite of Melanotan II without significant melanogenic activity.
Key Research Findings
FDA-approved in 2019 (Vyleesi) for hypoactive sexual desire disorder (HSDD) in premenopausal women. RECONNECT trials showed statistically significant increases in sexual desire and reduction in distress. First centrally-acting treatment for female sexual dysfunction.
Subcutaneous injection (as needed)
FDA Approved
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