Iseganan (IB-367)
Overview
Iseganan is a 17-amino acid synthetic analog of protegrin, a naturally occurring antimicrobial peptide found in porcine leukocytes. It disrupts microbial cell membranes via a beta-sheet structure stabilized by disulfide bonds, conferring broad-spectrum activity against bacteria, fungi, and some viruses. Iseganan was developed primarily as an oral rinse to prevent ventilator-associated pneumonia and oral mucositis in immunocompromised patients. Its rapid microbicidal action and low systemic absorption profile supported its formulation for topical oral use.
Key Research Findings
Phase III trials in ventilator-associated pneumonia prevention did not meet primary endpoints for reducing infection rates, leading to discontinuation of development for that indication. Studies in chemotherapy-induced oral mucositis similarly failed to demonstrate significant clinical benefit. Development was halted in the early 2000s following these trial results.
Oral rinse
Investigational
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