Goserelin (Zoladex)
Overview
A synthetic decapeptide GnRH agonist administered as a biodegradable subcutaneous implant that provides sustained drug release over 1 or 3 months. Like other GnRH agonists, goserelin initially stimulates and then suppresses the HPG axis, reducing sex hormone production to castrate or postmenopausal levels. The implant formulation eliminates the need for repeated injections and ensures compliance.
Key Research Findings
FDA-approved for prostate cancer, breast cancer, endometriosis, and endometrial thinning. The 10.8 mg depot provides 3 months of sustained hormone suppression. Equivalent efficacy to surgical castration in prostate cancer with the advantage of reversibility. Used as adjuvant therapy with radiation in locally advanced prostate cancer based on landmark trials (Bolla et al., NEJM, 1997).
Subcutaneous implant
FDA Approved
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