Gonadorelin (GnRH)
Overview
A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone. Gonadorelin stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary when administered in a pulsatile fashion. Continuous or high-dose administration paradoxically downregulates GnRH receptors, suppressing gonadotropin secretion, a principle exploited by GnRH agonist therapeutics.
Key Research Findings
FDA-approved for diagnostic evaluation of hypothalamic-pituitary-gonadal axis function and for induction of ovulation. Pulsatile GnRH pump therapy successfully restores fertility in hypothalamic amenorrhea patients. The diagnostic test measures LH response to distinguish hypothalamic from pituitary causes of hypogonadism.
Intravenous, Subcutaneous injection
FDA Approved
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