GHRP-2
Overview
A synthetic hexapeptide growth hormone secretagogue that acts on the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary to stimulate growth hormone release. GHRP-2 is one of the most potent GH-releasing peptides, producing robust GH pulses while also increasing ACTH, cortisol, and prolactin to a modest degree. It amplifies the natural GH axis and works synergistically with GHRH analogs.
Key Research Findings
Clinical studies demonstrated dose-dependent GH release with peak levels at 15-30 minutes post-administration. More potent than GHRP-6 with less appetite stimulation. Used clinically in Japan for GH stimulation testing. Research shows sustained IGF-1 elevation and improved body composition parameters.
Subcutaneous injection, Intravenous
Investigational
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CJC-1295
In Clinical TrialsA synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that binds to albumin, extending its half-life from minutes to approximately 6-8 days. CJC-1295 stimulates pulsatile GH release from the anterior pituitary by binding to GHRH receptors while preserving the natural GH secretory pattern and negative feedback mechanisms.
Ipamorelin
In Clinical TrialsA highly selective growth hormone secretagogue that acts on ghrelin/GHS receptors in the pituitary gland to stimulate GH release. Unlike other GH secretagogues, ipamorelin does not significantly affect ACTH, cortisol, or prolactin levels, making it one of the most specific GH-releasing peptides. It works synergistically with GHRH analogs like CJC-1295.
Sermorelin
FDA ApprovedA synthetic 29-amino acid analog of GHRH representing the shortest fully functional fragment of the native 44-amino acid hormone. Sermorelin stimulates the pituitary to produce and release growth hormone through the natural GHRH receptor pathway, preserving the hypothalamic-pituitary feedback axis. It maintains physiological pulsatile GH secretion patterns.
Tesamorelin (Egrifta)
FDA ApprovedA synthetic GHRH analog consisting of the 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid modification at the N-terminus to improve stability. Tesamorelin specifically targets visceral adipose tissue reduction by stimulating lipolysis through GH-mediated pathways. It is the only FDA-approved treatment for HIV-associated lipodystrophy.