Hexarelin
Overview
A synthetic hexapeptide growth hormone secretagogue with the highest GH-releasing potency among GHRPs. Hexarelin binds both GHS-R1a and CD36 (scavenger receptor), giving it unique cardiovascular properties independent of GH release.
Mechanism of Action
It exhibits cardioprotective effects through reduced atherosclerotic plaque formation and improved cardiac contractility via direct myocardial receptor activation..
Research Summary & Key Findings
Clinical trials demonstrated the most potent acute GH release among GHRPs. Unique CD36-mediated cardiovascular effects include improved cardiac output in heart failure patients and reduced lipid accumulation in macrophages. Subject to significant tachyphylaxis with chronic dosing, limiting long-term utility for GH augmentation (Broglio et al., J Endocrinol Invest, 2005).
Clinical Status
Hexarelin is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
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