Pentagastrin
Overview
A synthetic pentapeptide containing the C-terminal tetrapeptide sequence of gastrin (Trp-Met-Asp-Phe-NH2) linked to beta-alanine. Pentagastrin stimulates gastric acid secretion by binding to cholecystokinin-2 (CCK2) receptors on parietal cells, and stimulates calcitonin release from thyroid C-cells. It has been used as a diagnostic agent for both gastric acid secretory capacity testing and provocative testing for medullary thyroid carcinoma (MTC).
Key Research Findings
Historically used for gastric acid analysis (pentagastrin stimulation test) to assess maximal acid output. Pentagastrin-stimulated calcitonin test was a standard screening tool for MTC and MEN2 kindreds before genetic testing became available. Product availability has been limited in recent years in many countries. Largely superseded by genetic RET mutation testing for MTC screening and proton pump inhibitor trials for acid-related disorders.
Subcutaneous injection, Intramuscular injection
FDA Approved
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